China (Mainland)
1-Adamantanamine hydrochloride CAS NO.665-66-7
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98%(1-25)Kilogram
- Product Details
Keywords
- 665-66-7
- 1-Adamantanamine hydrochloride
- adamantane
Quick Details
- ProName: 1-Adamantanamine hydrochloride
- CasNo: 665-66-7
- Molecular Formula: C10H18ClN
- Appearance: almost white powder
- Application: 665-66-7
- DeliveryTime: 30 days
- PackAge: 25kg/drum
- Port: shanghai
- ProductionCapacity: 50 Metric Ton/Year
- Purity: 98%
- Storage: AMB
- Transportation: 665-66-7
- LimitNum: 1 Kilogram
Superiority
Molecular Structure: 
Molecular Formula: C10H18ClN
Molecular Weight: 187.71g/mol
CAS NO: 665-66-7
Mol File: 665-66-7.mol
EINECS: 211-560-2
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Melting Point: >300 °C(lit.)
Boiling point: 225.7 °C at 760 mmHg
Flash Point: 96 °C
Water Solubility: 50 mg/mL
Sensitive: Hygroscopic
Enthalpy of Vaporization: 46.22 kJ/mol
Vapour Pressure: 0.0852 mmHg at 25°C
Appearance: Crystalline Solid
IUPAC Name: Adamantan-1-amine hydrochloride
InChI : InChI=1/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
Smiles: Cl.C1C2CC3CC1CC(C3)(C2)N
Product Categories of Amantadine hydrochloride (CAS NO.665-66-7): Adamantane derivatives; chiral; Adamantanes; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Dopamine receptor
Details
Molecular Structure:
Molecular Formula: C10H18ClN
Molecular Weight: 187.71g/mol
CAS NO: 665-66-7
Mol File: 665-66-7.mol
EINECS: 211-560-2
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Melting Point: >300 °C(lit.)
Boiling point: 225.7 °C at 760 mmHg
Flash Point: 96 °C
Water Solubility: 50 mg/mL
Sensitive: Hygroscopic
Enthalpy of Vaporization: 46.22 kJ/mol
Vapour Pressure: 0.0852 mmHg at 25°C
Appearance: Crystalline Solid
IUPAC Name: Adamantan-1-amine hydrochloride
InChI : InChI=1/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
Smiles: Cl.C1C2CC3CC1CC(C3)(C2)N
Product Categories of Amantadine hydrochloride (CAS NO.665-66-7): Adamantane derivatives; chiral; Adamantanes; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Dopamine receptor
Amantadine hydrochloride (CAS NO.665-66-7) is used as NMDA-receptor antagonist.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 37mg/kg (37mg/kg) |
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969. |
| guinea pig | LD50 | oral | 360mg/kg (360mg/kg) |
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969. |
| man | LDLo | oral | 28571ug/kg (28.571mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE |
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988. |
| man | LDLo | oral | 286mg/kg (286mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: TOXIC PSYCHOSIS |
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988. |
| man | TDLo | oral | 13mg/kg/5D-I (13mg/kg) |
BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" |
American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985. |
| man | TDLo | oral | 24mg/kg/1D-I (24mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT |
Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990. |
| mouse | LD50 | intraperitoneal | 198mg/kg (198mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988. | |
| mouse | LD50 | intravenous | 95mg/kg (95mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988. | |
| mouse | LD50 | oral | 700mg/kg (700mg/kg) |
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969. |
| mouse | LD50 | subcutaneous | 290mg/kg (290mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988. | |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) |
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969. |
| rat | LD50 | intravenous | 90mg/kg (90mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988. | |
| rat | LD50 | oral | 800mg/kg (800mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988. | |
| rat | LD50 | subcutaneous | 500mg/kg (500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971. | |
| women | LDLo | oral | 50mg/kg (50mg/kg) |
BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: PULSE RATE |
American Journal of Medicine. Vol. 77, Pg. 388, 1984. |
Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: Xn
Risk Statements: 22-40-20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
40: Limited evidence of a carcinogenic effect
Safety Statements: 22-36/37-36
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves
The chemical synonyms of Amantadine hydrochloride (CAS NO.665-66-7): 1-Adamantanamine hydrochloride ; AI3-52211 ; Adamantanamine hydrochloride ; Adamantine hydrochloride ; Amantadine HCl ; Amantan ; Amazolon ; Aminoadamantane hydrochloride ; EXP 105-1 ; GP 38026 ; Influenol ; Mydantane ; NSC 83653 ; Symmetrel ; Trivaline ; UNII-M6Q1EO9TD0 ; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride (9CI) ; Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride .
